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• S6.E1 ∙ Matthew Shepard's Parents/Leeza Gibbons/The Browns from "Sister Wives"
• S6.E2 ∙ Brittany Maynard's Husband/Baywatch Stars/KC & the Sunshine Band
• S6.E3 ∙ A Former Oprah Show Guest's Shocking Discovery & Stunning Change of Heart
• S6.E4 ∙ Betty White/Belinda Carlisle/Tawny Kitaen/John Edwards
• S6.E5 ∙ Charles Spencer/Twisted Sister's Dee Snider/Erin from "The Waltons"
• S6.E6 ∙ Oprah Talks to Andrea Yates' Husband; Actress Angie Harmon & Apollonia
• S6.E7 ∙ Ricki Lake, DL Hughley, Garcelle Beauvais & Brutus the Grizzly Bear
• S6.E8 ∙ "Happy Days" Stars; Janice Dickinson & the World's First Openly Gay Prince
• S6.E9 ∙ The Unabomber's Brother, Leah Remini, Darryl Strawberry on Life After MLB
• S6.E10 ∙ Chef Curtis Stone; 90s Singer Lisa Loeb; Reality Star Taylor Armstrong
• S6.E23 ∙ The Members of R&B Music Group Bell Biv DeVoe; Snowboarder Amy Purdy; Country Music Singer Ty Herndon
• S6.E24 ∙ Catching Up with Gloria "I Will Survive" Gaynor, Singer Montell Jordan, Mel Harris ("Thirtysomething") and Actor John Amos ("Roots" and "Good Times")