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- S1.E1 ∙ George Clooney/Governor Jeb Bush/Mavis Staples & Friends
- S1.E2 ∙ Scarlett Johansson/Elon Musk/Kendrick Lamar
- S1.E3 ∙ Vice President Joe Biden/Travis Kalanick/Toby Keith
- S1.E4 ∙ Amy Schumer/Stephen King/Troubled Waters
- S1.E5 ∙ Emily Blunt/Justice Stephen Breyer/The Dead Weather
- S1.E6 ∙ Jake Gyllenhaal/Apple CEO Tim Cook/Run the Jewels & TV on the Radio
- S1.E7 ∙ Kevin Spacey/Carol Burnett/Abbi Jacobson & Ilana Glazer/Willie Nelson & John Mellencamp
- S1.E8 ∙ Trevor Noah/Ban Ki-Moon/Chris Stapleton
- S1.E9 ∙ Lupita Nyong'o/Sen. Bernie Sanders/Cast of "An American in Paris"
- S1.E10 ∙ Steph Curry/Sen. Ted Cruz/Don Henley
- S1.E11 ∙ Donald Trump/Ernest Moniz/Raury
- S1.E12 ∙ Hugh Jackman/Sen. Elizabeth Warren/Pearl Jam
- S1.E13 ∙ Andrew Sullivan/Maria Shriver/Jim Gaffigan/Archbishop Thomas Wenski
- S1.E14 ∙ Malala Yousafzai/Kerry Washington/The Arcs
- S1.E15 ∙ Michelle Obama/Mindy Kaling/John Legend
- S1.E16 ∙ Ellen Page/Jesse Eisenberg/Dominic Wilcox
- S1.E17 ∙ Elizabeth Gilbert/John Oliver/Evan Spiegel/Bill Withers/Ed Sheeran
- S1.E18 ∙ Secretary of State John Kerry/Claire Danes/PewDiePie
- S1.E19 ∙ Morgan Freeman/Ruth Wilson/Sean Murray
- S1.E20 ∙ John McCain/Yo-Yo Ma/Misty Copeland
- S1.E21 ∙ Bill Clinton/Billy Eichner/Florence and the Machine
- S1.E22 ∙ Gina Rodriguez/Ben Bernanke/Tame Impala
- S1.E23 ∙ Cate Blanchett/Airbnb CEO Brian Chesky
- S1.E24 ∙ James Corden/Shane Smith/Halsey
- S1.E25 ∙ Carey Mulligan/Elvis Costello/Darlene Love
- S1.E26 ∙ Sarah Silverman/Elijah Wood/The Legends of Zelda: Symphony of the Goddesses
- S1.E27 ∙ Jack Black/Nick Woodman/Michelle Dorrance
- S1.E28 ∙ Oprah Winfrey/Joseph Fink & Jeffrey Cranor/Judith Hill
- S1.E29 ∙ Jimmy Kimmel/"Crimson Peak" Cast/Beach House
- S1.E30 ∙ Sienna Miller/Melissa Benoist/Chance the Rapper
- S1.E31 ∙ Hillary Clinton/Anthony Bourdain/Carrie Brownstein/Lianne La Navas
- S1.E32 ∙ Julianna Margulies/Jonathan Franzen/Alabama Shakes
- S1.E33 ∙ Seth MacFarlane/Neil DeGrasse Tyson
- S1.E34 ∙ Charlie Rose/Stacy Schiff/Ghost/The Zombies
- S1.E35 ∙ Allison Janney/Colin Quinn/Margaret Cho
- S1.E36 ∙ Antonio Banderas/Reed Hastings/John Irving
- S1.E37 ∙ Daniel Craig/Elizabeth Gilbert/Dr. Eugenia Cheng
- S1.E38 ∙ Bryan Cranston/Karl Ove Knausgaard/Shamir
- S1.E39 ∙ Whoopi Goldberg/Gov. John Kasich/Glen Hansard
- S1.E40 ∙ Ethan Hawke/Sen. Claire McCaskill & Sen. Amy Klobuchar/Nathaniel Ratcliff & the Night Sweats
- S1.E41 ∙ Aziz Ansari/Shonda Rhimes/Bruce Campbell & Lucy Lawless
- S1.E42 ∙ Viola Davis/Brian Greene/George Ezra
- S1.E43 ∙ Jennifer Connelly/Judd Apatow/The Internet
- S1.E44 ∙ Mark Ruffalo/John Cleese/Micheal Flatley
- S1.E45 ∙ Capt. Florent Groberg/Bill Maher/Shepard Fairey/The Acro-Cats
- S1.E46 ∙ Julianne Moore/Burt Reynolds/Public Image Ltd./CeeLo Green
- S1.E47 ∙ Sharon Stone/Justin Theroux/James Taylor
- S1.E48 ∙ Jane Fonda/Andrew Lloyd Webber/Brandon Niederauer
- S1.E49 ∙ Michael Caine/Larry Wilmore/Boots/Vulfpeck
- S1.E50 ∙ Sylvester Stallone/Ted Koppel/My Morning Jacket